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Models of CHD2

As part of our "Roadmap to a Cure", we must ensure that any treatment we intend to use in people will be safe, efficacious and has the greatest potential to benefit people living with a CHD2 mutation. 


For these reasons, developing models of CHD2 that can be widely shared with the fewest barriers or commercially purchased is a top priority for our community.


Listed below is a growing list of models that can be used as tools for basic biology and translational-preclinical studies of CHD2.


CHD2 human iPSC line available through the European Bank for Induced Pluripotent Stem Cells


  • PFIZi029-A   ​Description: c4636 C>T in exon 36 of the CHD2 gene (NM_001271.3)


CHD2 human stable knockdown cell lines through AcceGen Biotech




CHD2 mouse model that has 2 nucleotide deletion in the 3rd exon of CHD2, which leads to production of little to no CHD2 protein. 


Chd2 mouse alleles available through The International Mouse Phenotyping Consortium and related phenotypic data


       Allele type: reporter-tagged deletion allele (with selection cassette)


       Allele type: KO first allele (reporter-tagged insertion with conditional potential)


       Allele type: Reporter-tagged deletion allele (post-Cre)


Chd2 mouse alleles available through Taconic Biosciences, Inc.


        Allele type: Gene trap





CHD2 mutant frog allele with a 22bp deletion within the second chromodomain, though not yet published.


For inquiries and additional information please contact, Helen Willsey, PhD @


Stock will be distributed through the National Xenopus Resource (NXR)

*If you have any assets ie. IPSC cells, mice, organoids, etc. that are not listed, please reach out to us so that we can be the conduit in helping to advance collaborative, team science endeavors.


Want to work with us and have questions about what model to use, contact us at

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